Ten days after bilateral electrolytic lesions of the nucleus basalis magnocellularis (NBM) (an experimental model of Alzheimer's disease), adult male Wistar rats were exposed to cold restraint stress in individual and social condition. Therefore, rats were placed into individual or group restraint boxes (composed of six single boxes) and exposed during 2 hr to the cold (4 degrees C). The results showed that: 1) there were no differences in type and intensity of stress-induced gastric lesions between single-stressed intact control (IC), sham-operated (SO) and NBM-lesioned rats, 2) the incidence, number and length of gastric erosions were significantly higher in group-stressed NBM-lesioned rats than in IC and SO rats, 3) the individual-stressed IC and SO rats have significantly higher incidence, number and length of gastric erosions as well as ulcer index than IC and SO group-stressed rats, and 4) there were no significant differences in intensity and type of acute gastric lesions betwee...n single- and group-stressed NBM-lesioned rats. Ir could be concluded that NBM lesions induce significant changes in social behavior in rats.
Ključne reči:
Alzheimer's disease / cold restraint / rat / social behavior / stress ulcer
Izvor:
International Journal of Neuroscience, 1998, 94, 3-4, 251-257
TY - JOUR
AU - Popović, M.
AU - Popović, N.
AU - Caballero-Bleda, M.
PY - 1998
UR - http://intor.torlakinstitut.com/handle/123456789/101
AB - Ten days after bilateral electrolytic lesions of the nucleus basalis magnocellularis (NBM) (an experimental model of Alzheimer's disease), adult male Wistar rats were exposed to cold restraint stress in individual and social condition. Therefore, rats were placed into individual or group restraint boxes (composed of six single boxes) and exposed during 2 hr to the cold (4 degrees C). The results showed that: 1) there were no differences in type and intensity of stress-induced gastric lesions between single-stressed intact control (IC), sham-operated (SO) and NBM-lesioned rats, 2) the incidence, number and length of gastric erosions were significantly higher in group-stressed NBM-lesioned rats than in IC and SO rats, 3) the individual-stressed IC and SO rats have significantly higher incidence, number and length of gastric erosions as well as ulcer index than IC and SO group-stressed rats, and 4) there were no significant differences in intensity and type of acute gastric lesions between single- and group-stressed NBM-lesioned rats. Ir could be concluded that NBM lesions induce significant changes in social behavior in rats.
PB - Taylor & Francis Ltd, Abingdon
T2 - International Journal of Neuroscience
T1 - Cold restraint-induced gastric lesions in individual-and group-stressed rats in an experimental model of Alzheimer's disease
EP - 257
IS - 3-4
SP - 251
VL - 94
DO - 10.3109/00207459808986450
UR - conv_103
ER -
@article{
author = "Popović, M. and Popović, N. and Caballero-Bleda, M.",
year = "1998",
abstract = "Ten days after bilateral electrolytic lesions of the nucleus basalis magnocellularis (NBM) (an experimental model of Alzheimer's disease), adult male Wistar rats were exposed to cold restraint stress in individual and social condition. Therefore, rats were placed into individual or group restraint boxes (composed of six single boxes) and exposed during 2 hr to the cold (4 degrees C). The results showed that: 1) there were no differences in type and intensity of stress-induced gastric lesions between single-stressed intact control (IC), sham-operated (SO) and NBM-lesioned rats, 2) the incidence, number and length of gastric erosions were significantly higher in group-stressed NBM-lesioned rats than in IC and SO rats, 3) the individual-stressed IC and SO rats have significantly higher incidence, number and length of gastric erosions as well as ulcer index than IC and SO group-stressed rats, and 4) there were no significant differences in intensity and type of acute gastric lesions between single- and group-stressed NBM-lesioned rats. Ir could be concluded that NBM lesions induce significant changes in social behavior in rats.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Cold restraint-induced gastric lesions in individual-and group-stressed rats in an experimental model of Alzheimer's disease",
pages = "257-251",
number = "3-4",
volume = "94",
doi = "10.3109/00207459808986450",
url = "conv_103"
}
Popović, M., Popović, N.,& Caballero-Bleda, M.. (1998). Cold restraint-induced gastric lesions in individual-and group-stressed rats in an experimental model of Alzheimer's disease. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 94(3-4), 251-257.
https://doi.org/10.3109/00207459808986450
conv_103
Popović M, Popović N, Caballero-Bleda M. Cold restraint-induced gastric lesions in individual-and group-stressed rats in an experimental model of Alzheimer's disease. in International Journal of Neuroscience. 1998;94(3-4):251-257.
doi:10.3109/00207459808986450
conv_103 .
Popović, M., Popović, N., Caballero-Bleda, M., "Cold restraint-induced gastric lesions in individual-and group-stressed rats in an experimental model of Alzheimer's disease" in International Journal of Neuroscience, 94, no. 3-4 (1998):251-257,
https://doi.org/10.3109/00207459808986450 .,
conv_103 .
