Cold restraint-induced gastric lesions in individual-and group-stressed rats in an experimental model of Alzheimer's disease
Abstract
Ten days after bilateral electrolytic lesions of the nucleus basalis magnocellularis (NBM) (an experimental model of Alzheimer's disease), adult male Wistar rats were exposed to cold restraint stress in individual and social condition. Therefore, rats were placed into individual or group restraint boxes (composed of six single boxes) and exposed during 2 hr to the cold (4 degrees C). The results showed that: 1) there were no differences in type and intensity of stress-induced gastric lesions between single-stressed intact control (IC), sham-operated (SO) and NBM-lesioned rats, 2) the incidence, number and length of gastric erosions were significantly higher in group-stressed NBM-lesioned rats than in IC and SO rats, 3) the individual-stressed IC and SO rats have significantly higher incidence, number and length of gastric erosions as well as ulcer index than IC and SO group-stressed rats, and 4) there were no significant differences in intensity and type of acute gastric lesions betwee...n single- and group-stressed NBM-lesioned rats. Ir could be concluded that NBM lesions induce significant changes in social behavior in rats.
Keywords:
Alzheimer's disease / cold restraint / rat / social behavior / stress ulcerSource:
International Journal of Neuroscience, 1998, 94, 3-4, 251-257Publisher:
- Taylor & Francis Ltd, Abingdon
DOI: 10.3109/00207459808986450
ISSN: 0020-7454
WoS: 000084098800008
Scopus: 2-s2.0-0032226740
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TorlakTY - JOUR AU - Popović, M. AU - Popović, N. AU - Caballero-Bleda, M. PY - 1998 UR - http://intor.torlakinstitut.com/handle/123456789/101 AB - Ten days after bilateral electrolytic lesions of the nucleus basalis magnocellularis (NBM) (an experimental model of Alzheimer's disease), adult male Wistar rats were exposed to cold restraint stress in individual and social condition. Therefore, rats were placed into individual or group restraint boxes (composed of six single boxes) and exposed during 2 hr to the cold (4 degrees C). The results showed that: 1) there were no differences in type and intensity of stress-induced gastric lesions between single-stressed intact control (IC), sham-operated (SO) and NBM-lesioned rats, 2) the incidence, number and length of gastric erosions were significantly higher in group-stressed NBM-lesioned rats than in IC and SO rats, 3) the individual-stressed IC and SO rats have significantly higher incidence, number and length of gastric erosions as well as ulcer index than IC and SO group-stressed rats, and 4) there were no significant differences in intensity and type of acute gastric lesions between single- and group-stressed NBM-lesioned rats. Ir could be concluded that NBM lesions induce significant changes in social behavior in rats. PB - Taylor & Francis Ltd, Abingdon T2 - International Journal of Neuroscience T1 - Cold restraint-induced gastric lesions in individual-and group-stressed rats in an experimental model of Alzheimer's disease EP - 257 IS - 3-4 SP - 251 VL - 94 DO - 10.3109/00207459808986450 ER -
@article{ author = "Popović, M. and Popović, N. and Caballero-Bleda, M.", year = "1998", abstract = "Ten days after bilateral electrolytic lesions of the nucleus basalis magnocellularis (NBM) (an experimental model of Alzheimer's disease), adult male Wistar rats were exposed to cold restraint stress in individual and social condition. Therefore, rats were placed into individual or group restraint boxes (composed of six single boxes) and exposed during 2 hr to the cold (4 degrees C). The results showed that: 1) there were no differences in type and intensity of stress-induced gastric lesions between single-stressed intact control (IC), sham-operated (SO) and NBM-lesioned rats, 2) the incidence, number and length of gastric erosions were significantly higher in group-stressed NBM-lesioned rats than in IC and SO rats, 3) the individual-stressed IC and SO rats have significantly higher incidence, number and length of gastric erosions as well as ulcer index than IC and SO group-stressed rats, and 4) there were no significant differences in intensity and type of acute gastric lesions between single- and group-stressed NBM-lesioned rats. Ir could be concluded that NBM lesions induce significant changes in social behavior in rats.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "International Journal of Neuroscience", title = "Cold restraint-induced gastric lesions in individual-and group-stressed rats in an experimental model of Alzheimer's disease", pages = "257-251", number = "3-4", volume = "94", doi = "10.3109/00207459808986450" }
Popović, M., Popović, N.,& Caballero-Bleda, M.. (1998). Cold restraint-induced gastric lesions in individual-and group-stressed rats in an experimental model of Alzheimer's disease. in International Journal of Neuroscience Taylor & Francis Ltd, Abingdon., 94(3-4), 251-257. https://doi.org/10.3109/00207459808986450
Popović M, Popović N, Caballero-Bleda M. Cold restraint-induced gastric lesions in individual-and group-stressed rats in an experimental model of Alzheimer's disease. in International Journal of Neuroscience. 1998;94(3-4):251-257. doi:10.3109/00207459808986450 .
Popović, M., Popović, N., Caballero-Bleda, M., "Cold restraint-induced gastric lesions in individual-and group-stressed rats in an experimental model of Alzheimer's disease" in International Journal of Neuroscience, 94, no. 3-4 (1998):251-257, https://doi.org/10.3109/00207459808986450 . .