TY  - JOUR
AU  - Kosec, Duško
AU  - Lavrnić, Dragana
AU  - Apostolski, Slobodan
AU  - Leposavić, Gordana
PY  - 2005
UR  - http://intor.torlakinstitut.com/handle/123456789/197
AB  - This study was undertaken to investigate T-cell maturation ill hyperplastic thymi of patients suffering from myasthenia gravis (MG). For this purpose, the expression of the major differentiational molecules (CD4, CD8, and CD3/TCRalphass) and that of the regulator. v and activation molecules oil thymocytes from MG patients and control subjects were estimated by flow cytometric analysis. In the MG patients the increase in relative proportion of immature (CD4-8- TCRalphass-) and the most mature (CD4+8- TCRalphass(high) and CD4-8- TCRhigh encompassing immunoregulatory NKT) thymocytes followed by a decrease in that of CD4+8+CD3 /TCRalphass- cells was found. Furthermore, in these patients the relative proportion of CD4+HLA-DR+ and CD4+71+ cells was increased, whereas that of CD4+25+ cells was slightly, but significantly, decreased (reflecting, most likely, decreased contribution of T reg cells bearing this phenotype). Moreover. in MG thymi the percentage of CD45RA+ cells was reduced indicating changes in the selection processes. In keeping with this finding the reduced thymocyte apoptotic index and percentage of cells bearing apoptosing (CD4-8- TCRalphass(low)) phenotype were detected. In conclusion, the study demonstrates substantial changes in intrathymic differentiation of T cells in hyperplastic MG thymi and suggests alterations in selection events providing an increased escape of potentially? autoreactive T-cell clones, on one side, and all altered maturation and/or selection of immunoregulatory cells (NKT and CD4+8-25+ T reg cells) keeping these cell clones under control, on the other side.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Changes in thymopoiesis in myasthenia gravis
EP  - 243
IS  - 2
SP  - 223
VL  - 115
DO  - 10.1080/00207450590519472
ER  - 

@article{
author = "Kosec, Duško and Lavrnić, Dragana and Apostolski, Slobodan and Leposavić, Gordana",
year = "2005",
abstract = "This study was undertaken to investigate T-cell maturation ill hyperplastic thymi of patients suffering from myasthenia gravis (MG). For this purpose, the expression of the major differentiational molecules (CD4, CD8, and CD3/TCRalphass) and that of the regulator. v and activation molecules oil thymocytes from MG patients and control subjects were estimated by flow cytometric analysis. In the MG patients the increase in relative proportion of immature (CD4-8- TCRalphass-) and the most mature (CD4+8- TCRalphass(high) and CD4-8- TCRhigh encompassing immunoregulatory NKT) thymocytes followed by a decrease in that of CD4+8+CD3 /TCRalphass- cells was found. Furthermore, in these patients the relative proportion of CD4+HLA-DR+ and CD4+71+ cells was increased, whereas that of CD4+25+ cells was slightly, but significantly, decreased (reflecting, most likely, decreased contribution of T reg cells bearing this phenotype). Moreover. in MG thymi the percentage of CD45RA+ cells was reduced indicating changes in the selection processes. In keeping with this finding the reduced thymocyte apoptotic index and percentage of cells bearing apoptosing (CD4-8- TCRalphass(low)) phenotype were detected. In conclusion, the study demonstrates substantial changes in intrathymic differentiation of T cells in hyperplastic MG thymi and suggests alterations in selection events providing an increased escape of potentially? autoreactive T-cell clones, on one side, and all altered maturation and/or selection of immunoregulatory cells (NKT and CD4+8-25+ T reg cells) keeping these cell clones under control, on the other side.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Changes in thymopoiesis in myasthenia gravis",
pages = "243-223",
number = "2",
volume = "115",
doi = "10.1080/00207450590519472"
}

Kosec, D., Lavrnić, D., Apostolski, S.,& Leposavić, G.. (2005). Changes in thymopoiesis in myasthenia gravis. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 115(2), 223-243.
https://doi.org/10.1080/00207450590519472

Kosec D, Lavrnić D, Apostolski S, Leposavić G. Changes in thymopoiesis in myasthenia gravis. in International Journal of Neuroscience. 2005;115(2):223-243.
doi:10.1080/00207450590519472 .

Kosec, Duško, Lavrnić, Dragana, Apostolski, Slobodan, Leposavić, Gordana, "Changes in thymopoiesis in myasthenia gravis" in International Journal of Neuroscience, 115, no. 2 (2005):223-243,
https://doi.org/10.1080/00207450590519472 . .